Spider-Man is a fictional superhero created by Stan Lee in August 1962 as part of the Marvel Universe comics. When Spider-Man isn’t flying around fighting crime using his super strength and agility, wall adhesion abilities, “web-shooters”, and spidey-senses, he’s just another typical high school student, Peter Parker. After his parents die when he’s young, Parker moves in with his Uncle Ben and Aunt May in New York City. While visiting a science exhibit, Parker is bitten by a radioactiove spider, giving him “the agility and proportionate strength of an arachnid." Peter Parker quickly takes on the identity of Spider-Man to help his city, but he struggles to balance his personal life, work, and school.

In 1999, Spider-Man was featured in Fastlane, an eight-part anti-marijuana insert that appeared in the middle of every Marvel comic to warn children and teens about the dangers of marijuana. Gregg Schigiel created Fastlane in conjunction with the White House Office of National Drug Control Policy as part of a media campaign to educate the younger audience about negative influences in the media. In the comic series, Spider-Man fights Mysterio and the effects of marijuana as depicted in the comics with the introduction of movie star Zane Whelan who promotes marijuana use.