4 Things You Didn’t Know About the Science of Getting High

Smoking marijuana and getting high is seen as a lazy, leisure activity, but there’s actually a science behind it. When cannabis consumers smoke, the chemicals and compounds in the marijuana react with receptors and cells in the body to produce a unique high experience. Everyone reacts to cannabis in their own way depending on their body’s response and the way in which the marijuana is consumed. Many users feel high immediately after smoking, because the brain and body responds to chemical reactions.

When cannabis is consumed, its effects depend on where the cannabinoids react with the body, depending on which recognition proteins, or receptors they attach to. CB1 is one of these receptors which is concentrated in the brain and responsible for getting users high. The second receptor is CB2, which is found throughout the body on cells of the immune system. THC can interact with both receptors, which is why and how it has recreational and medicinal purposes. Now, the reason for the common case of “the munchies” is also associated with science and CB1 receptors, which bind with cannabinoids to tell the body when it’s hungry. THC is a cannabinoid, so when consumed it basically artificially boosts this “I’m hungry” signal to the brain, which ultimately causes “the munchies”.


Academy Award winning filmmaker Spike Jonze has been tapped by the upscale cannabis producer and retailer MedMen to direct a short film on cannabis history. There are few details available about Jonze's cannabis focused short film for the California-based dispensary chain. However, Jesse Williams of 'Grey's Anatomy' fame is slated to appear in the film and shooting has already begun in LA, according to The Hollywood Reporter.

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